United States Publication 20070231273

20070231273

Method for Decreasing Blood Glucose Levels

Published:  October 4, 2007

Inventors:  Wu; Jie; (Avondale, AZ)

Abstract:  A method for decreasing blood glucose levels is disclosed. Iptakalim hydrochloride (a SUR1 subunit-dependent K.sub.ATP channel blocker and a SUR2 subunit-selective K.sub.ATP channel opener) is used to block pancreatic .beta.-cell K.sub.ATP channels, which depolarizes .beta.-cells, elevates intracellular Ca.sup.2+ concentrations, and in turn increases insulin release. Therefore, in some implementations, iptakalim hydrochloride is an optimal treatment for type-2 diabetic patients with cardiovascular disorders.